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Tianlong Viral DNA/RNA Extraction Kit (4.0L) for HPV Screening

Views:633     Author:Site Editor     Publish Time: 2021-08-28      Origin:Site

Cervical cancer is the fourth most common malignancy among women globally, with an estimated 570,000 new cases in 2018, and the burden is projected to continue to increase to nearly 700,000 cases and 400,000 deaths in 2030 (Bray et al., 2018).1


Almost all cervical cancer is caused by HPV. There are more than 100 types of HPV, of which at least 14 are cancer-causing (also known as high-risk type). It can take only 5 to 10 years in women with weakened immune systems, such as those with untreated HIV infection. HPV vaccination and screening are recommended by WHO for prevention cervical cancer. When screening detects an HPV infection or pre-cancerous lesions, these can easily be treated, and cervical cancer can be avoided.

On July 6, 2021, WHO released “WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition”, recommending using HPV DNA detection as the primary screening test rather than VIA or cytology in screening and treatment approaches among both the general population of women and women living with HIV.


The Viral DNA/RNA Extraction Kit (4.0L), developed and manufactured by Tianlong, is compatible with Tianlong Rotary Nucleic Acid Extractor GeneRotex 48, is designed with a loading volume of 1000μL per well, which enables the extraction and enriching of HPV DNA in samples much faster and more efficient than the conventional 200μL (1-well) or 1000μL (2-well) loading volume methods (e.g. Tianlong Nucleic Acid Extraction Kit for HPV DNA Extraction) and can greatly optimize the sensitivity of downstream HPV detection for cervical cancer screening.


Note:  Tianlong Nucleic Acid Extraction Kit for HPV DNA Extraction: 2-well loading volume of 1000μL, compatible with Tianlong Libex, GeneRotex 96, PANA9600S, etc.


The correlation coefficients (square values – R2) between the test Ct values and the dilution factor were all > 0.980.


The CV values of the 4.0L kit and the conventional HPV extraction kit were both less than 2%; the 4.0L kit presented lower Ct values and higher sensitivity.

Cervical cancer is the only type of human cancer with a clear cause, HPV, which has a recommended screening test to detect it at an early stage.

Tianlong has always been ready to combat HPV and eliminate cervical cancer for the well-being of women everywhere.

  1. Bray, F., Ferlay, J., Soerjomataram, I., et al. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424.




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