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Human Survival Motor Neuron 1 (SMN1) Gene Detection Kit (PCR-Melting Curve Method)

Based on real-time PCR, Tianlong SMN1 gene detection kit can identify the copy-number variation of the SMN1 at exons 7 and/or 8, by the primers designed for ARMS-PCR and melting curve method, and two copies of the housekeeping gene as the internal reference. The results after being processed by compatible devices and software can identify SMN1 carrier for SMA genetic testing.
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Product Description

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PRODUCT PRINCIPLES

Based on real-time PCR, Tianlong SMN1 gene detection kit can identify the copy-number variation of the SMN1 at exons 7 and/or 8, by the primers designed for ARMS-PCR and melting curve method, and two copies of the housekeeping gene as the internal reference. The results after being processed by compatible devices and software can identify SMN1 carrier for SMA genetic testing.

SIGNIFICANCE

Preconception or prenatal carrier screening for SMA.

Help to achieve early treatment for patient benefit.

FEATURES

  • INTERNATIONAL STANDARD

EU CE-Certified, and approved and marketed worldwide.

  • ACCURATE

High-specificity probes, quantified reactions, for able to identify both heterozygous and homozygous deletions of SMN1 gene.

  • FAST AND EASY

Compatible with Tianlong automated nucleic acid extraction systems, easy to operate using real-time PCR method; testing and reporting completed in about 2h.

  • ECONOMIC

Fast and lower cost compared with other methods such as PCR-RFLP or MLPA.

  • SAFE

Automation ready; tube closed throughout the testing procedures; minimized contamination.


Product Parameters

Product NameHuman Survival Motor Neuron 1 (SMN1) Gene Detection Kit (PCR-Melting Curve Method)
Detection TargetsCopy number of SMN1 exons 7 and/or 8 in human genomic DNA
Limit of Detection (LOD)10 ng/uL
PrecisionVariable cofficient of Ct value (CV, %)≤6%
Sample TypeWhole blood
No. of Tests /Kit32T/Kit
Storage Temperature-15℃ to -25℃ for 10 months
Compatible InstrumentsTianlong Gentier 96E, Gentier 96R and similar instruments


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