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The 2020 National Science and Technology Awards Conference was held in Beijing on Nov 3. Tianlong received the 2020 National Science and Technology Progress Award. Prof. PENG Niancai, General Manager Dr. LI Ming, CTO Dr. MIAO Baogang of Tianlong team were listed as the Top 3 individuals of this award for the outstanding contribution to scientific and technological innovation.
Key technologies for high-throughput automated quantitative multiplex nucleic acid detection and their applications
High-end high-throughput multiplex nucleic acid testing instruments were primarily imported for a long time in China. The industry-academia-research team of Tianlong led by Prof. PENG Niancai, professor of Xi'an Jiaotong University and founder of Tianlong, has been working on the key technologies for nucleic acid detection instruments and reagents for over 20 years and has solved the critical technical problems, such as cross-contamination in nucleic acid extraction, poor temperature uniformity during rapid thermal cycling gene amplification, integrated Micro-Electro-Mechanical System (MEMS) biosensing and multiplex nucleic acid detection with the support of China's National Key R&D Program for Important Scientific Instruments and Equipment. The achievements include the innovations of high-throughput automated quantitative multiplex nucleic acid detection, 12 models of instrumentations of 5 categories for 96-throughput 6-channel high-throughput multiplex real-time PCR systems, and automatic nucleic acid workstations, as well as over 200 nucleic acid extraction and real-time PCR kits of 10 categories, which together can form integrated high-throughput automated quantitative testing system solutions and product portfolio. Tianlong team also led the development of the national pharmaceutical industry standard, "YY/T1717-2020 Nucleic Acid Extraction Kit (Magnetic Bead Method)" to fill the gaps in China.
The global COVID-19 pandemic struck at the end of 2019 and has posed a severe threat to people's lives and health worldwide. Tianlong project is the only awarded project in the 2020 National Science and Technology Awards directly related to nucleic acid detection by overcoming high-end technological difficulties for major needs. And it has been verified in the applications in epidemic prevention and control of significant outbreaks of infectious diseases such as avian influenza, Ebola, and swine fever. Tianlong has equipped more than 30 provinces, municipalities, and autonomous regions to prevent and control the COVID-19 pandemic. Tianlong team and products detected the first confirmed cases in Sichuan, Yunnan, Heilongjiang, Shaanxi, etc. After the epidemic subsided in Wuhan, Tianlong team rushed to help the outbreak areas, including Suifenhe in Heilongjiang, Shulan in Jilin, Beijing, Xinjiang, Qingdao in Shandong, Fuyang in Anhui, Tianjin, Pudong in Shanghai, Zhangjiajie in Hunan Province, Xiamen in Fujian, Xi'an in Shaanxi, etc. It provided a total of over 20,000 instruments, over 200 million testing kits to the CDCs and medical institutions in more than 70 countries and regions worldwide. Domestically, Tianlong instruments and devices are applied in over 80% of the top 100 hospitals in China, 9 of the top 10 hospitals in China, and national and all the provincial CDCs. To improve the national nucleic acid testing capacity, Tianlong has also actively responded to the relevant policies. Tianlong products have been installed and applied in over 90% of the 100 national public testing laboratories for the good of the public and the infrastructure construction for epidemic prevention and control.
Tianlong has played a key role in the technology innovation to transition from complete dependence on imports to independent large-scale applications and received multiple letters of appreciation from the Joint Prevention and Control Mechanism of the State Council (Medical Supplies) and China National CDC. The outstanding performance of the nucleic acid detection products for COVID-19 has met the needs domestically as a significant contribution to the prevention and control of the pandemic within the chain of "early diagnosis, early isolation, control the epidemic, reduce the infection and lower the mortality." Internationally, Tianlong products have been exported to and applied in the top 1 independent clinical laboratories and medical institutions.
Tianlong products are from China and for pandemic fighting worldwide.